Tranilast Reduces Pathological Cardiac Fibrosis and Improves Diastolic Function Following Kidney Dysfunction: Implication for Cardio-Renal Syndrome
نویسندگان
چکیده
منابع مشابه
Diminazene Aceturate Improves Cardiac Fibrosis and Diastolic Dysfunction in Rats with Kidney Disease
Angiotensin converting enzyme (ACE) 2 is a negative regulator of the renin angiotensin system (RAS) through its role to degrade angiotensin II. In rats with subtotal nephrectomy (STNx), adverse cardiac remodelling occurs despite elevated cardiac ACE2 activity. We hypothesised that diminazene aceturate (DIZE), which has been described as having an off-target effect to activate ACE2, would have b...
متن کاملExperimental mild renal insufficiency mediates early cardiac apoptosis, fibrosis, and diastolic dysfunction: a kidney-heart connection.
Impaired renal function with loss of nephron number in chronic renal disease (CKD) is associated with increased cardiovascular morbidity and mortality. However, the structural and functional cardiac response to early and mild reduction in renal mass is poorly defined. We hypothesized that mild renal impairment produced by unilateral nephrectomy (UNX) would result in early cardiac fibrosis and i...
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BACKGROUND Renal dysfunction is associated with a higher rate of atrial fibrillation in clinical practice. This study investigated the associations between renal function, left ventricular (LV) diastolic dysfunction, and postoperative atrial fibrillation (POAF). METHODS AND RESULTS A total of 265 consecutive patients who underwent cardiac surgery were prospectively enrolled in the study. Echo...
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ژورنال
عنوان ژورنال: Heart, Lung and Circulation
سال: 2012
ISSN: 1443-9506
DOI: 10.1016/j.hlc.2012.05.246